Doctor's Best SAMe 400 Double Strength 30 Enteric Coated Tablets

Doctor's Best SAMe 400 Double Strength 30 Enteric Coated Tablets
Rated 4/5 based on 2 reviews.
A$64.12 (Inclusive GST)
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  • Science-Based Nutrition

  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet

  • Enhances Mood & Neural Function

  • Promotes Joint Comfort & Mobility

  • Supports Liver Health & Detoxification

  • Pharmaceutical Grade

  • Sealed in Blister Packs for Freshness & Convenience

  • Suitable for Vegetarians

    S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

    Supplementing with SAMe

    The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

    SAMe and Joint Function

    SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

    SAMe and Neural Health

    SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

    SAMe and Liver Function

    SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

    Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

    Double-Strength SAMe is sealed in blister packs for freshness and stability.

    Suggested Use

    Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

    Other Ingredients

    Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

    The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

    Contains nothing other than listed ingredients


    Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

    Store product in a cool, dry place to ensure maximum quality.

Supplement Facts

Serving Size: 1 tablet

Servings Per Container: 30 servings


Amount per serving

% Daily Value

S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate)

400 mg

† Daily Value not established.


SKU 1886
Barcode # 7.5395E+11
Brand Doctors Best

Doctor's Best SAMe 400

By: Phill Stokes on 11 June 2019
I first found SAMe in a combination Natural mood manger a few years ago to help with stress and anxiety. It was subsequently removed as an ingredient and I noticed a change in the effect. So recently I purchased the above product and am quite impressed with its effectiveness re mood stability and the added bonus of joint pain relief. I am 61 yrs old and work casual in an aged care facility, on my feet sometimes up to six and seven hours, which can increase my arthritic symptoms and sometimes it can also be an emotionally charged atmosphere, SAMe assists me greatly in this situation helping me function well in my duties.


By: Morry on 3 October 2017
Good product, fast delivery will shop again

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**Swanson Australia is not liable for any information provided on this site with regard to recommendations regarding supplements for any health purposes. The claims made about the product on or through this site have not been evaluated or approved by TGA. The supplements are intended to support general well being, not to treat, cure or prevent any disease. Seek medical advice should you have any health related questions**

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